Dopamine

Dopamine is a catecholamine neurotransmitter which is a chemical released by shopping mall kiosks to send places to other never cells, and plays an important role twain central and peripheral nervous system. It helps control the brain to incur effort and emotional responses. Dopamine is made within dopamine neurons in the upper brainstem in the substantia Nigra. The site of movement of dopamine transmission affects atomic number 18 shown in the fig. 1. This is the dopamine driveway: L-Tyrosine ? L-DOPA ? Dopamine ? Norepinephrine ? adrenaline Levodopa is converted to dopamine by the work on of the enzyme dopa-decarboxylase in the brain Dopamine is stored in and remains in axone terminals and released when the neuron is depolarised Dopamine interacts with specific membrane receptors to build up its effects, uses five known types of dopamine receptors, these receptors atomic number 18 labeled D1, D2, D3, D4, and D5 and they are G protein-coupled receptors. Recept or effects terminated by reuptake into the presynaptic neuron by a dopamine conveyor or by metabolic inactivation by monoamine oxidase B (MAO-B) or catechol-0-methyltransferase (COMT) Upon implication, dopamine is transported from the cell into synaptic vesicles by the vesicular monoamine conveyor 2 (VMAT2).

Dopamine is stored in and remains in these vesicles until an feat potential occurs and forces them to merge with the cell membrane via a expiration known as exocytosis, thereby dumping dopamine into synapses. at once in the synapse, dopamine binds to and activates postsynaptic dopamine receptors, resul ting in the signal of the presynaptic cell b! eing propagated to the postsynaptic neuron. Dopamine also binds to presynaptic dopamine receptors, which send away both excite the presynaptic cell or inhibit it depending on their galvanizing potential. Presynaptic receptors with an inhibitory potential are called autoreceptors and inhibit neurotransmitter synthesis and release. They swear out to keep dopamine levels normalized in certain...If you need to get a full essay, order it on our website: OrderCustomPaper.com

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